STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HNF4AUncharacterized protein. (476 aa)    
Predicted Functional Partners:
AFP
Alpha fetoprotein.
   
  
 0.785
PPARGC1A
PPARG coactivator 1 alpha.
    
 
 0.768
GSC
Goosecoid homeobox.
    
 
 0.713
W5PXZ3_SHEEP
Uncharacterized protein.
   
  
 0.704
HNF1A
HNF1 homeobox A.
   
 0.696
NR0B2
Nuclear receptor subfamily 0 group B member 2.
   
0.625
MED1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.603
PCK1
Phosphoenolpyruvate carboxykinase 1.
   
  
 0.580
HNF1B
HNF1 homeobox B.
   
 0.578
NCOA1
Nuclear receptor coactivator.
   
 
 0.571
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (36%) [HD]