STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5P1G2_SHEEPF-box domain-containing protein. (657 aa)    
Predicted Functional Partners:
ELOB
Elongin B.
    
 0.914
LEO1
LEO1 homolog, Paf1/RNA polymerase II complex component.
    
 0.911
SSRP1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
 0.870
ELOC
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
 0.842
W5PA39_SHEEP
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
 0.842
W5Q945_SHEEP
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
 0.842
CTR9
CTR9 homolog, Paf1/RNA polymerase II complex component.
    
 0.788
POLR2B
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.776
CDK9
Cyclin dependent kinase 9.
     
 0.747
RPL18A
60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
    
   0.736
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.