STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRAF4TNF receptor-associated factor. (454 aa)    
Predicted Functional Partners:
TRADD
TNFRSF1A associated via death domain.
    
 0.822
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]
    
 0.717
ERN2
Endoplasmic reticulum to nucleus signaling 2.
   
 0.660
IRAK4
Protein kinase domain-containing protein.
   
 0.654
BIRC6
Baculoviral IAP repeat containing 6.
    
 0.649
TMEM189-UBE2V1
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.645
IRAK2
Interleukin 1 receptor associated kinase 2.
   
 0.640
IRAK3
Interleukin 1 receptor associated kinase 3.
   
 0.612
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.604
MIB2
Mindbomb E3 ubiquitin protein ligase 2.
    
 0.592
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.