close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SKA1Spindle and kinetochore associated complex subunit 1. (255 aa)    
Predicted Functional Partners:
SKA3
Spindle and kinetochore associated complex subunit 3.
   
 0.994
SKA2
Spindle and kinetochore associated complex subunit 2.
   
 0.990
PLK1
Serine/threonine-protein kinase PLK.
   
 
 0.972
NUF2
NUF2 component of NDC80 kinetochore complex.
   
  
 0.904
NDC80
NDC80 kinetochore complex component.
   
 0.899
CDC20
Cell division cycle 20.
   
 
 0.896
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 
 0.894
CDC20B
Cell division cycle 20B.
   
 
 0.887
ZW10
Zw10 kinetochore protein.
      
 0.873
ZWILCH
Zwilch kinetochore protein.
   
  
 0.870
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.