STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5P2S9_SHEEPGOLD domain-containing protein. (218 aa)    
Predicted Functional Partners:
W5Q575_SHEEP
GOLD domain-containing protein; Belongs to the EMP24/GP25L family.
   
 0.863
TMED3
Transmembrane p24 trafficking protein 3.
   
0.646
W5QGK4_SHEEP
GOLD domain-containing protein.
  
0.605
STX5
Syntaxin 5; Belongs to the syntaxin family.
   
 0.589
TMED7
GOLD domain-containing protein.
   
0.580
TMED1
Transmembrane p24 trafficking protein 1.
    
 
 0.576
TMED5
Transmembrane p24 trafficking protein 5.
    
 
 0.565
TICAM1
TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.
   
 0.552
LOC105601870
TIR domain-containing protein.
   
 0.552
COPB1
Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
   
 0.550
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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