node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | CPA3 | ENSOARP00000003247 | ENSOARP00000005665 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Carboxypeptidase A3. | 0.456 |
AGT | LOC101116249 | ENSOARP00000003247 | ENSOARP00000006926 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.476 |
AGT | LOC114109029 | ENSOARP00000003247 | ENSOARP00000004835 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.700 |
AGT | LOC114112429 | ENSOARP00000003247 | ENSOARP00000007026 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.476 |
AGT | W5P9F4_SHEEP | ENSOARP00000003247 | ENSOARP00000007062 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.476 |
CPA3 | AGT | ENSOARP00000005665 | ENSOARP00000003247 | Carboxypeptidase A3. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.456 |
CPA3 | LOC114109029 | ENSOARP00000005665 | ENSOARP00000004835 | Carboxypeptidase A3. | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.524 |
CPA3 | TPSB2 | ENSOARP00000005665 | ENSOARP00000015758 | Carboxypeptidase A3. | Tryptase-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily. | 0.538 |
KITLG | LOC114109029 | ENSOARP00000016728 | ENSOARP00000004835 | Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.756 |
LOC101116249 | AGT | ENSOARP00000006926 | ENSOARP00000003247 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.476 |
LOC101116249 | LOC114109029 | ENSOARP00000006926 | ENSOARP00000004835 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.512 |
LOC101116249 | LOC114112429 | ENSOARP00000006926 | ENSOARP00000007026 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.901 |
LOC101116249 | W5P9F4_SHEEP | ENSOARP00000006926 | ENSOARP00000007062 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.928 |
LOC114109029 | AGT | ENSOARP00000004835 | ENSOARP00000003247 | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.700 |
LOC114109029 | CPA3 | ENSOARP00000004835 | ENSOARP00000005665 | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | Carboxypeptidase A3. | 0.524 |
LOC114109029 | KITLG | ENSOARP00000004835 | ENSOARP00000016728 | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] | 0.756 |
LOC114109029 | LOC101116249 | ENSOARP00000004835 | ENSOARP00000006926 | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.512 |
LOC114109029 | LOC114112429 | ENSOARP00000004835 | ENSOARP00000007026 | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.504 |
LOC114109029 | PRSS27 | ENSOARP00000004835 | ENSOARP00000020077 | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | Serine protease 27; Belongs to the peptidase S1 family. | 0.518 |
LOC114109029 | TPSB2 | ENSOARP00000004835 | ENSOARP00000015758 | Mast cell protease 2; Putative mast cell chymase; Belongs to the peptidase S1 family. Granzyme subfamily. | Tryptase-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily. | 0.531 |