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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)    
Predicted Functional Partners:
SOD1-2
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
   
 0.979
MRPL17
Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.
   
 0.959
MRPL3
Mitochondrial ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.
  
 
 0.958
PPARGC1A
PPARG coactivator 1 alpha.
     
 0.955
MRPL46
Mitochondrial ribosomal protein L46.
   
 
 0.955
MRPL47
Mitochondrial ribosomal protein L47.
   
 
 0.954
RPS11
Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.
  
 
 0.953
DAP3
Death associated protein 3.
   
 
 0.952
YBEY
YbeY metalloendoribonuclease.
   
 
 0.950
MRPL43
Mitochondrial ribosomal protein L43.
   
 
 0.944
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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