STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF187Ring finger protein 187. (230 aa)    
Predicted Functional Partners:
ANGEL1
Angel homolog 1.
      
 0.850
ELF3
E74 like ETS transcription factor 3.
      
 0.775
RAMP3
Receptor activity modifying protein 3.
      
 0.727
PKDCC
Protein kinase domain containing, cytoplasmic.
    
 0.671
EIF4H
Eukaryotic translation initiation factor 4H.
   
 
 0.612
PTPN5
Protein tyrosine phosphatase non-receptor type 5.
      
 0.582
TRIM44
Tripartite motif containing 44.
    
 
 0.565
LGALS8
Galectin.
    
 
 0.525
W5PDP3_SHEEP
Uncharacterized protein.
  
   
 0.517
CA2
Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity). Reversible hydration of carbon dioxide.
   
  
 0.517
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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