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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STIP1Stress induced phosphoprotein 1. (592 aa)    
Predicted Functional Partners:
PRNP
Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...]
    
 0.940
HSP90AA1
Heat shock protein alpha.
   
 0.914
HSP90AB1
Heat shock protein 90 alpha family class B member 1.
   
 0.914
PTGES3
Prostaglandin E synthase 3.
   
 0.879
TRAP1
TNF receptor associated protein 1.
   
 0.853
TSC1
TSC complex subunit 1.
   
 0.853
HSPA1A-2
Uncharacterized protein; Belongs to the heat shock protein 70 family.
   
 0.847
HSPA1A
annotation not available
   
 0.847
HSPA8
Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.
   
 0.813
HSPA4
Uncharacterized protein.
   
 0.789
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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