STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCP-3Mast cell protease 3. (264 aa)    
Predicted Functional Partners:
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 0.942
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
    
 0.938
CASP8
Caspase 8; Belongs to the peptidase C14A family.
    
 0.931
MCL1
MCL1 apoptosis regulator, BCL2 family member.
   
 
 0.923
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 0.908
CASP7
Caspase 7; Belongs to the peptidase C14A family.
    
 0.908
PARP3
PARP alpha-helical domain-containing protein.
   
 
  0.903
PARP4
Poly [ADP-ribose] polymerase.
   
 
  0.903
PARP2
Poly [ADP-ribose] polymerase.
   
  0.903
CD4
T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.
   
 0.901
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.