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PRNP protein (Ovis aries) - STRING interaction network
"PRNP" - Major prion protein in Ovis aries
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
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Experiments
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[Homology]
Score
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (256 aa)    
Predicted Functional Partners:
FYN
FYN proto-oncogene, Src family tyrosine kinase (537 aa)
         
  0.924
HSPA5
Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (656 aa)
       
  0.906
STIP1
Uncharacterized protein (592 aa)
       
  0.905
NCAM1
Neural cell adhesion molecule 1 (850 aa)
     
  0.894
PRND
Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity); Belongs to the prion family (178 aa)
       
 
  0.856
NCAM2
Neural cell adhesion molecule 2 (837 aa)
     
  0.851
GSS
Glutathione synthetase (474 aa)
       
 
  0.842
CRYAB
Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (175 aa)
     
 
  0.839
MSMB
Beta-microseminoprotein; Microseminoprotein, beta-; Belongs to the beta-microseminoprotein family (114 aa)
           
  0.829
LAMC1
Laminin, gamma 1 (formerly LAMB2) (1610 aa)
         
    0.800
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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