SCN9A protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SCN9A

Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1989 aa)

Predicted Functional Partners:

UNC79

0.908

SCN1B

0.905

CALHM1

0.902

SCN2A

0.901

SCN3A

0.901

SCN2B

0.858

SCN4B

0.731

CASP9

0.700

SCN3B

0.682

W5QA57_SHEEP

0.584

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALHM1	SCN2A	ENSOARP00000004410	ENSOARP00000005796	Calcium homeostasis modulator 1.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.902
CALHM1	SCN3A	ENSOARP00000004410	ENSOARP00000005914	Calcium homeostasis modulator 1.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.902
CALHM1	SCN9A	ENSOARP00000004410	ENSOARP00000005012	Calcium homeostasis modulator 1.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.902
CASP9	SCN2A	ENSOARP00000010405	ENSOARP00000005796	Caspase 9; Belongs to the peptidase C14A family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.521
CASP9	SCN3A	ENSOARP00000010405	ENSOARP00000005914	Caspase 9; Belongs to the peptidase C14A family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.521
CASP9	SCN9A	ENSOARP00000010405	ENSOARP00000005012	Caspase 9; Belongs to the peptidase C14A family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.700
CASP9	W5QA57_SHEEP	ENSOARP00000010405	ENSOARP00000019600	Caspase 9; Belongs to the peptidase C14A family.	MH1 domain-containing protein.	0.536
SCN1B	SCN2A	ENSOARP00000005004	ENSOARP00000005796	Sodium voltage-gated channel beta subunit 1.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.901
SCN1B	SCN2B	ENSOARP00000005004	ENSOARP00000008858	Sodium voltage-gated channel beta subunit 1.	Sodium voltage-gated channel beta subunit 2.	0.984
SCN1B	SCN3A	ENSOARP00000005004	ENSOARP00000005914	Sodium voltage-gated channel beta subunit 1.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.896
SCN1B	SCN3B	ENSOARP00000005004	ENSOARP00000000697	Sodium voltage-gated channel beta subunit 1.	Sodium voltage-gated channel beta subunit 3.	0.517
SCN1B	SCN4B	ENSOARP00000005004	ENSOARP00000008739	Sodium voltage-gated channel beta subunit 1.	Sodium voltage-gated channel beta subunit 4.	0.981
SCN1B	SCN9A	ENSOARP00000005004	ENSOARP00000005012	Sodium voltage-gated channel beta subunit 1.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.905
SCN2A	CALHM1	ENSOARP00000005796	ENSOARP00000004410	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Calcium homeostasis modulator 1.	0.902
SCN2A	CASP9	ENSOARP00000005796	ENSOARP00000010405	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Caspase 9; Belongs to the peptidase C14A family.	0.521
SCN2A	SCN1B	ENSOARP00000005796	ENSOARP00000005004	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium voltage-gated channel beta subunit 1.	0.901
SCN2A	SCN2B	ENSOARP00000005796	ENSOARP00000008858	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium voltage-gated channel beta subunit 2.	0.881
SCN2A	SCN3A	ENSOARP00000005796	ENSOARP00000005914	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.900
SCN2A	SCN3B	ENSOARP00000005796	ENSOARP00000000697	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium voltage-gated channel beta subunit 3.	0.761
SCN2A	SCN4B	ENSOARP00000005796	ENSOARP00000008739	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium voltage-gated channel beta subunit 4.	0.693

page 1 of 4

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About