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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RXFP1Relaxin family peptide receptor 1. (760 aa)    
Predicted Functional Partners:
RLN3
Relaxin 3.
   
 
 0.994
INSL3
Insulin-like protein 3.
   
 0.989
RXFP3
Relaxin family peptide receptor 3.
     
 0.985
RXFP4
G_PROTEIN_RECEP_F1_2 domain-containing protein.
     
 0.969
RXFP2
Relaxin family peptide receptor 2.
  
0.935
GNAI2
Uncharacterized protein.
    
 0.915
GNAI1
G protein subunit alpha i1.
    
 0.915
GNAI3
G protein subunit alpha i3.
    
 0.915
W5PUC3_SHEEP
Reverse transcriptase domain-containing protein.
   
 
 0.906
RSPO4
R-spondin 4.
   
 0.814
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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