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The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1057 aa)    
Predicted Functional Partners:
MARCHF7
Membrane associated ring-CH-type finger 7.
   
 
 0.846
ZMYM5
Zinc finger MYM-type containing 5.
      
 0.828
W5Q2D0_SHEEP
Ubiquitin carboxyl-terminal hydrolase.
      
 0.759
UCHL3
Ubiquitin carboxyl-terminal hydrolase.
      
 0.759
WBP2
WW domain binding protein 2.
    
 
 0.734
MRTO4
Uncharacterized protein.
      
 0.715
UBE2A
Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.700
ANKRD46
Ankyrin repeat domain 46.
   
 
 0.681
PSMA8
Proteasome subunit alpha type.
    
 
 0.668
RCCD1
RCC1 domain containing 1.
    
0.667
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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