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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF280BZinc finger protein 280B. (543 aa)    
Predicted Functional Partners:
PRAME
Preferentially expressed antigen in melanoma.
      
 0.828
W5PH95_SHEEP
Uncharacterized protein.
     
 0.773
CLCN7
Chloride channel protein.
      
 0.727
SLC5A4
Solute carrier family 5 member 4; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      
 0.725
CDYL
Chromodomain Y like.
    
 
 0.659
SETD4
SET domain containing 4.
    
 0.607
TDRD15
Tudor domain containing 15.
    
 
 0.586
MRPL48
Mitochondrial ribosomal protein L48.
    
 
 0.580
GLYAT
Uncharacterized protein.
      
 0.567
LOC101103085
Uncharacterized protein.
    
 
 0.561
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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