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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM135BFamily with sequence similarity 135 member B. (1404 aa)    
Predicted Functional Partners:
PPP1R42
Protein phosphatase 1 regulatory subunit 42.
      
 0.776
RUSC2
RUN and SH3 domain containing 2.
      
 0.774
RUSC1
Uncharacterized protein.
      
 0.755
DEPDC7
DEP domain containing 7.
      
 0.733
TTC22
Tetratricopeptide repeat domain 22.
      
 0.707
FAM228B
Uncharacterized protein.
      
 0.707
VPS35L
VPS35 endosomal protein sorting factor like.
   
  
 0.700
FAM110A
Family with sequence similarity 110 member A.
      
 0.692
FAM177A1
Family with sequence similarity 177 member A1.
      
 0.685
KLHL29
Kelch like family member 29.
      
 0.660
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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