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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFDNAfadin, adherens junction formation factor. (1810 aa)    
Predicted Functional Partners:
NECTIN2
Nectin cell adhesion molecule 2.
    
 0.895
NECTIN3
Nectin cell adhesion molecule 3.
    
 0.891
NECTIN1
Nectin cell adhesion molecule 1.
    
 0.884
F11R
F11 receptor.
    
 0.797
VCL
Vinculin.
    
 
 0.790
TJP1
Tight junction protein 1; Belongs to the MAGUK family.
   
 
 0.741
PDZD11
PDZ domain containing 11.
     
 0.680
TJP2
Uncharacterized protein; Belongs to the MAGUK family.
   
 
 0.665
CPEB3
Cytoplasmic polyadenylation element binding protein 3.
      
 0.654
ARHGAP6
Rho GTPase activating protein 6.
      
 0.653
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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