Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TMX3Thioredoxin related transmembrane protein 3. (454 aa)    
Predicted Functional Partners:
RIC3
RIC3 acetylcholine receptor chaperone.
    
 0.899
UNC50
Unc-50 inner nuclear membrane RNA binding protein.
      
 0.814
SCCPDH
Saccharopine dehydrogenase (putative).
      
 0.806
TMX1
Thioredoxin related transmembrane protein 1.
   
 
0.790
TMX4
Thioredoxin related transmembrane protein 4.
   
 
 0.753
CANX
Calnexin.
    
 0.748
SCAMP3
Secretory carrier-associated membrane protein.
   
  
 0.706
ERGIC3
ERGIC and golgi 3.
   
 
 0.703
SCAMP2
Secretory carrier-associated membrane protein.
   
  
 0.689
LMAN1
Lectin, mannose binding 1.
   
 
 0.620
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (10%) [HD]