TCF4 protein (Ovis aries) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Gene Fusion

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[Homology]

Score

TCF4

Transcription factor 4. (763 aa)

Predicted Functional Partners:

CTNNB1

0.972

TAL1

0.880

NANOG

0.819

ASCL1

0.815

MYOD1

0.800

MYF5

0.754

ASCL4

0.745

MYOG

0.734

LMO2

0.731

POU5F1

0.719

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	POU5F1	ENSOARP00000017049	ENSOARP00000010730	Achaete-scute family bHLH transcription factor 1.	POU domain protein.	0.464
ASCL1	TCF4	ENSOARP00000017049	ENSOARP00000005381	Achaete-scute family bHLH transcription factor 1.	Transcription factor 4.	0.815
ASCL4	TCF4	ENSOARP00000019870	ENSOARP00000005381	Uncharacterized protein.	Transcription factor 4.	0.745
CTNNB1	MYOD1	ENSOARP00000003072	ENSOARP00000022800	Catenin beta 1.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.478
CTNNB1	NANOG	ENSOARP00000003072	ENSOARP00000002340	Catenin beta 1.	Homeobox domain-containing protein.	0.761
CTNNB1	POU5F1	ENSOARP00000003072	ENSOARP00000010730	Catenin beta 1.	POU domain protein.	0.812
CTNNB1	TCF4	ENSOARP00000003072	ENSOARP00000005381	Catenin beta 1.	Transcription factor 4.	0.972
LMO2	TAL1	ENSOARP00000019346	ENSOARP00000003681	LIM domain only 2.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.994
LMO2	TCF4	ENSOARP00000019346	ENSOARP00000005381	LIM domain only 2.	Transcription factor 4.	0.731
MYF5	MYOD1	ENSOARP00000016262	ENSOARP00000022800	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.488
MYF5	MYOG	ENSOARP00000016262	ENSOARP00000001076	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	BASIC domain-containing protein.	0.689
MYF5	TCF4	ENSOARP00000016262	ENSOARP00000005381	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Transcription factor 4.	0.754
MYOD1	CTNNB1	ENSOARP00000022800	ENSOARP00000003072	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	Catenin beta 1.	0.478
MYOD1	MYF5	ENSOARP00000022800	ENSOARP00000016262	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.488
MYOD1	MYOG	ENSOARP00000022800	ENSOARP00000001076	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	BASIC domain-containing protein.	0.786
MYOD1	NANOG	ENSOARP00000022800	ENSOARP00000002340	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	Homeobox domain-containing protein.	0.411
MYOD1	POU5F1	ENSOARP00000022800	ENSOARP00000010730	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	POU domain protein.	0.490
MYOD1	TCF4	ENSOARP00000022800	ENSOARP00000005381	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	Transcription factor 4.	0.800
MYOG	MYF5	ENSOARP00000001076	ENSOARP00000016262	BASIC domain-containing protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.689
MYOG	MYOD1	ENSOARP00000001076	ENSOARP00000022800	BASIC domain-containing protein.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.786