TCF4 protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	TCF3	ENSOARP00000017049	ENSOARP00000013391	Achaete-scute family bHLH transcription factor 1.	Transcription factor 3.	0.869
ASCL1	TCF4	ENSOARP00000017049	ENSOARP00000005381	Achaete-scute family bHLH transcription factor 1.	Transcription factor 4.	0.806
CTNNB1	MYOD1	ENSOARP00000003072	ENSOARP00000022800	Catenin beta 1.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.442
CTNNB1	NANOG	ENSOARP00000003072	ENSOARP00000002340	Catenin beta 1.	Homeobox domain-containing protein.	0.747
CTNNB1	TCF3	ENSOARP00000003072	ENSOARP00000013391	Catenin beta 1.	Transcription factor 3.	0.973
CTNNB1	TCF4	ENSOARP00000003072	ENSOARP00000005381	Catenin beta 1.	Transcription factor 4.	0.858
ID1	ID3	ENSOARP00000001150	ENSOARP00000007843	Inhibitor of DNA binding 1, HLH protein.	BHLH domain-containing protein.	0.967
ID1	MYOD1	ENSOARP00000001150	ENSOARP00000022800	Inhibitor of DNA binding 1, HLH protein.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.938
ID1	MYOG	ENSOARP00000001150	ENSOARP00000001076	Inhibitor of DNA binding 1, HLH protein.	BASIC domain-containing protein.	0.657
ID1	TCF3	ENSOARP00000001150	ENSOARP00000013391	Inhibitor of DNA binding 1, HLH protein.	Transcription factor 3.	0.952
ID1	TCF4	ENSOARP00000001150	ENSOARP00000005381	Inhibitor of DNA binding 1, HLH protein.	Transcription factor 4.	0.788
ID3	ID1	ENSOARP00000007843	ENSOARP00000001150	BHLH domain-containing protein.	Inhibitor of DNA binding 1, HLH protein.	0.967
ID3	TCF3	ENSOARP00000007843	ENSOARP00000013391	BHLH domain-containing protein.	Transcription factor 3.	0.957
ID3	TCF4	ENSOARP00000007843	ENSOARP00000005381	BHLH domain-containing protein.	Transcription factor 4.	0.783
MYF6	MYOD1	ENSOARP00000016249	ENSOARP00000022800	Myogenic factor 6.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.550
MYF6	MYOG	ENSOARP00000016249	ENSOARP00000001076	Myogenic factor 6.	BASIC domain-containing protein.	0.561
MYF6	TCF3	ENSOARP00000016249	ENSOARP00000013391	Myogenic factor 6.	Transcription factor 3.	0.866
MYF6	TCF4	ENSOARP00000016249	ENSOARP00000005381	Myogenic factor 6.	Transcription factor 4.	0.775
MYOD1	CTNNB1	ENSOARP00000022800	ENSOARP00000003072	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	Catenin beta 1.	0.442
MYOD1	ID1	ENSOARP00000022800	ENSOARP00000001150	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	Inhibitor of DNA binding 1, HLH protein.	0.938