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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHOX2APaired like homeobox 2A. (286 aa)    
Predicted Functional Partners:
HAND2
Heart and neural crest derivatives expressed 2.
   
 
 0.794
ASCL1
Achaete-scute family bHLH transcription factor 1.
   
 
 0.749
W5NYJ5_SHEEP
Cu2_monoox_C domain-containing protein.
   
  
 0.700
SOX10
SRY-box transcription factor 10.
   
  
 0.618
TH
Tyrosine hydroxylase.
   
  
 0.616
OLIG3
Oligodendrocyte transcription factor 3.
   
  
 0.589
BARX2
Homeobox protein BarH-like 2; Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia; Belongs to the BAR homeobox family.
   
  
 0.588
SLC6A7
Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
   
 
 0.585
W5NYP2_SHEEP
C2H2-type domain-containing protein.
   
  
 0.553
ISL1
ISL LIM homeobox 1.
      
 0.553
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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