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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TXNL1Thioredoxin like 1. (287 aa)    
Predicted Functional Partners:
PSMD14
Proteasome 26S subunit, non-ATPase 14.
   
 
 0.895
COPS5
COP9 signalosome subunit 5.
   
 
 0.864
ITSN2
Intersectin 2.
     
 0.798
SLC25A39
Solute carrier family 25 member 39; Belongs to the mitochondrial carrier (TC 2.A.29) family.
   
    0.780
MRPS33
Mitochondrial ribosomal protein S33.
      
 0.718
COPS6
COP9 signalosome subunit 6.
   
 
 0.679
DNAJC3
DnaJ heat shock protein family (Hsp40) member C3.
   
 
 0.674
ITSN1
Intersectin 1.
     
 0.631
CLTC
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
   
 
  0.602
PSMC3
Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.
   
   0.597
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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