STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THBDThrombomodulin. (555 aa)    
Predicted Functional Partners:
F2
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 0.997
PROCR
Protein C receptor.
     
 0.986
TFPI2
Tissue factor pathway inhibitor.
   
 
 0.936
DGKE
Diacylglycerol kinase.
      
 0.929
F3
Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
     
 0.918
TFPI
Tissue factor pathway inhibitor.
    
 
 0.909
W5PWS0_SHEEP
Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
    
 0.900
ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13.
    
 0.861
C2
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 0.845
LOC105611355
Uncharacterized protein.
    
 0.809
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.