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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEZ6L2Seizure related 6 homolog like 2. (909 aa)    
Predicted Functional Partners:
TMEM25
Transmembrane protein 25.
      
 0.832
TMEM91
Transmembrane protein 91.
      
 0.813
ANKRD13B
Ankyrin repeat domain 13B.
    
 
 0.805
ASPHD1
Aspartate beta-hydroxylase domain containing 1.
 
 
  
 0.800
FRMPD4
FERM and PDZ domain containing 4.
   
  
 0.799
CACHD1
Cache domain containing 1.
      
 0.774
NETO2
Neuropilin and tolloid like 2.
      
 0.774
TSPAN6
Tetraspanin.
   
  
 0.737
EML1
EMAP like 1.
    
 0.728
PLPPR3
Phospholipid phosphatase related 3.
   
 0.728
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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