STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101104705SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)    
Predicted Functional Partners:
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
    
 0.960
SERPINE1
SERPIN domain-containing protein; Belongs to the serpin family.
  
  
0.927
LOC101105044
SERPIN domain-containing protein; Belongs to the serpin family.
  
  
 
0.900
PLAU
Uncharacterized protein.
    
 0.685
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 0.677
PLAUR
Uncharacterized protein.
   
 0.631
F2
Uncharacterized protein; Belongs to the peptidase S1 family.
   
 0.571
MMP25
Matrix metallopeptidase 25.
   
 0.533
PSMB1
Proteasome subunit beta.
    
 0.516
DDI1
DNA damage inducible 1 homolog 1.
      
 0.479
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.