STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMCN1Hemicentin 1. (5590 aa)    
Predicted Functional Partners:
AOAH
Acyloxyacyl hydrolase.
      
 0.723
GPR142
G protein-coupled receptor 142; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.715
MAST3
Microtubule associated serine/threonine kinase 3.
      
 0.627
ELMO1
Engulfment and cell motility 1.
     
 0.617
OR6F1
Olfactory receptor.
    
 
 0.597
OR11L1
Olfactory receptor.
    
 
 0.597
PTGS2
Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]
      
 0.568
EXTL1
Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.
      
 0.540
TMEM252
Transmembrane protein 252.
      
 0.533
TRPT1
tRNA phosphotransferase 1.
      
 0.521
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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