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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STOX1Storkhead box 1. (877 aa)    
Predicted Functional Partners:
LRRC3B
Leucine rich repeat containing 3B.
      
 0.696
CCAR1
Cell division cycle and apoptosis regulator 1.
      
 0.692
DCAF6
DDB1 and CUL4 associated factor 6.
    
 
 0.691
MRVI1
Murine retrovirus integration site 1 homolog.
      
 0.673
FLVCR2
Feline leukemia virus subgroup C cellular receptor family member 2.
      
 0.616
ENG
Endoglin.
      
 0.579
ACVR2A
Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      
 0.565
DDX50
DExD-box helicase 50.
      
 0.538
TACR2
Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family.
      
 0.538
GASK1B
Golgi associated kinase 1B.
      
 0.538
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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