STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa)    
Predicted Functional Partners:
CCND3
Uncharacterized protein; Belongs to the cyclin family.
   
 0.999
CCND2
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
   
 0.999
CCND1
Cyclin_C domain-containing protein.
   
 0.999
CDKN1A
Uncharacterized protein.
   
 0.994
CDKN1B
Cyclin dependent kinase inhibitor 1B.
   
 0.994
CCNE1
Cyclin E1; Belongs to the cyclin family.
   
 0.992
CDKN2C
Cyclin dependent kinase inhibitor 2C.
   
 0.992
RB1
RB transcriptional corepressor 1.
   
 0.990
CCNA2
Cyclin A2; Belongs to the cyclin family.
   
 0.983
CDK6
Cyclin dependent kinase 6.
  
 
0.982
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.