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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (468 aa)    
Predicted Functional Partners:
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.894
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.864
TMEM189-UBE2V1
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
 0.753
IRAK4
Protein kinase domain-containing protein.
    
 0.744
IQCC
IQ motif containing C.
      
 0.693
W5P4Q7_SHEEP
Uncharacterized protein.
      
 0.693
IRAK2
Interleukin 1 receptor associated kinase 2.
    
 0.692
NKIRAS2
NFKB inhibitor interacting Ras like 2.
      
 0.676
CPAMD8
C3 and PZP like alpha-2-macroglobulin domain containing 8.
      
 0.614
KCNA10
Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family.
      
 0.613
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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