LOC101114909 protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC101114909

Death domain-containing protein. (250 aa)

Predicted Functional Partners:

FADD

0.603

KLHL18

0.537

CASP8

0.527

W5P6Q4_SHEEP

0.522

STXBP4

0.513

CDX4

0.469

W5QEW7_SHEEP

0.469

RAPSN

0.438

RELT

0.412

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	FADD	ENSOARP00000018175	ENSOARP00000019828	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	LOC101114909	ENSOARP00000018175	ENSOARP00000005830	Caspase 8; Belongs to the peptidase C14A family.	Death domain-containing protein.	0.527
CDX4	LOC101114909	ENSOARP00000019279	ENSOARP00000005830	Caudal type homeobox 4.	Death domain-containing protein.	0.469
FADD	CASP8	ENSOARP00000019828	ENSOARP00000018175	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.999
FADD	LOC101114909	ENSOARP00000019828	ENSOARP00000005830	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Death domain-containing protein.	0.603
FADD	W5P6Q4_SHEEP	ENSOARP00000019828	ENSOARP00000006108	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Death domain-containing protein.	0.524
KLHL18	LOC101114909	ENSOARP00000004611	ENSOARP00000005830	Kelch like family member 18.	Death domain-containing protein.	0.537
KLHL18	RAPSN	ENSOARP00000004611	ENSOARP00000007292	Kelch like family member 18.	Receptor associated protein of the synapse.	0.416
KLHL18	STXBP4	ENSOARP00000004611	ENSOARP00000005382	Kelch like family member 18.	Syntaxin binding protein 4.	0.490
LOC101114909	CASP8	ENSOARP00000005830	ENSOARP00000018175	Death domain-containing protein.	Caspase 8; Belongs to the peptidase C14A family.	0.527
LOC101114909	CDX4	ENSOARP00000005830	ENSOARP00000019279	Death domain-containing protein.	Caudal type homeobox 4.	0.469
LOC101114909	FADD	ENSOARP00000005830	ENSOARP00000019828	Death domain-containing protein.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.603
LOC101114909	KLHL18	ENSOARP00000005830	ENSOARP00000004611	Death domain-containing protein.	Kelch like family member 18.	0.537
LOC101114909	RAPSN	ENSOARP00000005830	ENSOARP00000007292	Death domain-containing protein.	Receptor associated protein of the synapse.	0.438
LOC101114909	RELT	ENSOARP00000005830	ENSOARP00000008229	Death domain-containing protein.	RELT TNF receptor.	0.412
LOC101114909	STXBP4	ENSOARP00000005830	ENSOARP00000005382	Death domain-containing protein.	Syntaxin binding protein 4.	0.513
LOC101114909	W5P6Q4_SHEEP	ENSOARP00000005830	ENSOARP00000006108	Death domain-containing protein.	Death domain-containing protein.	0.522
LOC101114909	W5QEW7_SHEEP	ENSOARP00000005830	ENSOARP00000021265	Death domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.469
RAPSN	KLHL18	ENSOARP00000007292	ENSOARP00000004611	Receptor associated protein of the synapse.	Kelch like family member 18.	0.416
RAPSN	LOC101114909	ENSOARP00000007292	ENSOARP00000005830	Receptor associated protein of the synapse.	Death domain-containing protein.	0.438