SEMA4A protein (Ovis aries) - STRING interaction network

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

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Score

SEMA4A

Semaphorin 4A; Belongs to the semaphorin family. (762 aa)

Predicted Functional Partners:

PLXNB2-2

0.986

PLXND1

0.979

PLXNB2

0.896

PLXNB1

0.789

PLXNA1

0.754

MET

0.611

NRP1

0.601

PLXNA4

0.591

PLXNB3

0.587

PLXNA3

0.585

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MET	NRP1	ENSOARP00000000815	ENSOARP00000018770	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Neuropilin; Belongs to the neuropilin family.	0.548
MET	PLXNB1	ENSOARP00000000815	ENSOARP00000000644	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B1.	0.950
MET	PLXNB2	ENSOARP00000000815	ENSOARP00000021272	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B2.	0.654
MET	PLXNB2-2	ENSOARP00000000815	ENSOARP00000011857	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PSI domain-containing protein.	0.933
MET	PLXNB3	ENSOARP00000000815	ENSOARP00000007319	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B3.	0.872
MET	SEMA4A	ENSOARP00000000815	ENSOARP00000005987	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Semaphorin 4A; Belongs to the semaphorin family.	0.611
NRP1	MET	ENSOARP00000018770	ENSOARP00000000815	Neuropilin; Belongs to the neuropilin family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.548
NRP1	PLXNA1	ENSOARP00000018770	ENSOARP00000008017	Neuropilin; Belongs to the neuropilin family.	Plexin A1.	0.983
NRP1	PLXNA3	ENSOARP00000018770	ENSOARP00000004634	Neuropilin; Belongs to the neuropilin family.	Plexin A3.	0.998
NRP1	PLXNA4	ENSOARP00000018770	ENSOARP00000006909	Neuropilin; Belongs to the neuropilin family.	Plexin A4.	0.997
NRP1	PLXNB1	ENSOARP00000018770	ENSOARP00000000644	Neuropilin; Belongs to the neuropilin family.	Plexin B1.	0.815
NRP1	PLXNB2	ENSOARP00000018770	ENSOARP00000021272	Neuropilin; Belongs to the neuropilin family.	Plexin B2.	0.562
NRP1	PLXNB2-2	ENSOARP00000018770	ENSOARP00000011857	Neuropilin; Belongs to the neuropilin family.	PSI domain-containing protein.	0.510
NRP1	PLXNB3	ENSOARP00000018770	ENSOARP00000007319	Neuropilin; Belongs to the neuropilin family.	Plexin B3.	0.680
NRP1	PLXND1	ENSOARP00000018770	ENSOARP00000014629	Neuropilin; Belongs to the neuropilin family.	Plexin D1.	0.868
NRP1	SEMA4A	ENSOARP00000018770	ENSOARP00000005987	Neuropilin; Belongs to the neuropilin family.	Semaphorin 4A; Belongs to the semaphorin family.	0.601
PLXNA1	NRP1	ENSOARP00000008017	ENSOARP00000018770	Plexin A1.	Neuropilin; Belongs to the neuropilin family.	0.983
PLXNA1	PLXNA3	ENSOARP00000008017	ENSOARP00000004634	Plexin A1.	Plexin A3.	0.548
PLXNA1	PLXNA4	ENSOARP00000008017	ENSOARP00000006909	Plexin A1.	Plexin A4.	0.550
PLXNA1	PLXNB1	ENSOARP00000008017	ENSOARP00000000644	Plexin A1.	Plexin B1.	0.523