STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101102276Uncharacterized protein. (201 aa)    
Predicted Functional Partners:
DSN1
DSN1 component of MIS12 kinetochore complex.
    
 0.989
NSL1
NSL1 component of MIS12 kinetochore complex.
    
 0.976
MIS12
Uncharacterized protein.
    
 0.907
LOC101117679
Uncharacterized protein.
    
 0.907
SPC24
SPC24 component of NDC80 kinetochore complex.
   
 0.846
NUF2
NUF2 component of NDC80 kinetochore complex.
    
 0.839
ZWINT
ZW10 interacting kinetochore protein.
    
 
 0.784
CENPC
Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions; Belongs to the CENP-C/MIF2 family.
    
 
 0.758
SPC25
SPC25 component of NDC80 kinetochore complex.
    
  0.728
NDC80
NDC80 kinetochore complex component.
    
 0.718
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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