node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | DCN | ENSOARP00000020204 | ENSOARP00000016893 | CD44 molecule (Indian blood group). | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.404 |
CD44 | MMP2 | ENSOARP00000020204 | ENSOARP00000019362 | CD44 molecule (Indian blood group). | Uncharacterized protein. | 0.707 |
CD44 | MMP7 | ENSOARP00000020204 | ENSOARP00000006547 | CD44 molecule (Indian blood group). | ZnMc domain-containing protein. | 0.868 |
CD44 | SPP1 | ENSOARP00000020204 | ENSOARP00000002753 | CD44 molecule (Indian blood group). | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.998 |
CD44 | TIMP1 | ENSOARP00000020204 | ENSOARP00000014098 | CD44 molecule (Indian blood group). | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | 0.529 |
CTSV | ELANE | ENSOARP00000008997 | ENSOARP00000010400 | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | 0.498 |
CTSV | MMP7 | ENSOARP00000008997 | ENSOARP00000006547 | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | ZnMc domain-containing protein. | 0.767 |
CTSV | OPTC | ENSOARP00000008997 | ENSOARP00000001814 | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | Opticin. | 0.544 |
DCN | CD44 | ENSOARP00000016893 | ENSOARP00000020204 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | CD44 molecule (Indian blood group). | 0.404 |
DCN | MMP2 | ENSOARP00000016893 | ENSOARP00000019362 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Uncharacterized protein. | 0.901 |
DCN | MMP7 | ENSOARP00000016893 | ENSOARP00000006547 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | ZnMc domain-containing protein. | 0.816 |
DCN | SPP1 | ENSOARP00000016893 | ENSOARP00000002753 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.725 |
DCN | TIMP2 | ENSOARP00000016893 | ENSOARP00000003474 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | NTR domain-containing protein. | 0.449 |
DCN | TIMP3 | ENSOARP00000016893 | ENSOARP00000019543 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Metallopeptidase inhibitor 3. | 0.470 |
ELANE | CTSV | ENSOARP00000010400 | ENSOARP00000008997 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | 0.498 |
ELANE | MMP7 | ENSOARP00000010400 | ENSOARP00000006547 | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. | ZnMc domain-containing protein. | 0.856 |
MMP2 | CD44 | ENSOARP00000019362 | ENSOARP00000020204 | Uncharacterized protein. | CD44 molecule (Indian blood group). | 0.707 |
MMP2 | DCN | ENSOARP00000019362 | ENSOARP00000016893 | Uncharacterized protein. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.901 |
MMP2 | MMP7 | ENSOARP00000019362 | ENSOARP00000006547 | Uncharacterized protein. | ZnMc domain-containing protein. | 0.788 |
MMP2 | OPTC | ENSOARP00000019362 | ENSOARP00000001814 | Uncharacterized protein. | Opticin. | 0.736 |