W5P9M9_SHEEP protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

W5P9M9_SHEEP

SERPIN domain-containing protein; Belongs to the serpin family. (391 aa)

Predicted Functional Partners:

CTSV

0.765

CTSS

0.576

CTSK

0.576

PGLYRP4

0.544

F2

0.535

SLC4A9

0.482

KAT14

0.479

TRAF3IP3

0.427

KRT32

0.403

CRNN

0.402

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRNN	KRT32	ENSOARP00000022671	ENSOARP00000017897	Cornulin.	Keratin 32; Belongs to the intermediate filament family.	0.724
CRNN	PGLYRP4	ENSOARP00000022671	ENSOARP00000000403	Cornulin.	Peptidoglycan recognition protein 4.	0.581
CRNN	W5P9M9_SHEEP	ENSOARP00000022671	ENSOARP00000007138	Cornulin.	SERPIN domain-containing protein; Belongs to the serpin family.	0.402
CTSK	CTSV	ENSOARP00000022430	ENSOARP00000008997	Cathepsin K; Belongs to the peptidase C1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.545
CTSK	W5P9M9_SHEEP	ENSOARP00000022430	ENSOARP00000007138	Cathepsin K; Belongs to the peptidase C1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.576
CTSS	CTSV	ENSOARP00000022421	ENSOARP00000008997	Cathepsin S; Belongs to the peptidase C1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.947
CTSS	W5P9M9_SHEEP	ENSOARP00000022421	ENSOARP00000007138	Cathepsin S; Belongs to the peptidase C1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.576
CTSV	CTSK	ENSOARP00000008997	ENSOARP00000022430	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	Cathepsin K; Belongs to the peptidase C1 family.	0.545
CTSV	CTSS	ENSOARP00000008997	ENSOARP00000022421	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.947
CTSV	W5P9M9_SHEEP	ENSOARP00000008997	ENSOARP00000007138	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.765
F2	W5P9M9_SHEEP	ENSOARP00000004316	ENSOARP00000007138	Uncharacterized protein; Belongs to the peptidase S1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.535
KAT14	W5P9M9_SHEEP	ENSOARP00000019685	ENSOARP00000007138	Lysine acetyltransferase 14.	SERPIN domain-containing protein; Belongs to the serpin family.	0.479
KRT32	CRNN	ENSOARP00000017897	ENSOARP00000022671	Keratin 32; Belongs to the intermediate filament family.	Cornulin.	0.724
KRT32	W5P9M9_SHEEP	ENSOARP00000017897	ENSOARP00000007138	Keratin 32; Belongs to the intermediate filament family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.403
PGLYRP4	CRNN	ENSOARP00000000403	ENSOARP00000022671	Peptidoglycan recognition protein 4.	Cornulin.	0.581
PGLYRP4	W5P9M9_SHEEP	ENSOARP00000000403	ENSOARP00000007138	Peptidoglycan recognition protein 4.	SERPIN domain-containing protein; Belongs to the serpin family.	0.544
SLC4A9	W5P9M9_SHEEP	ENSOARP00000018913	ENSOARP00000007138	Anion exchange protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.482
TRAF3IP3	W5P9M9_SHEEP	ENSOARP00000013838	ENSOARP00000007138	TRAF3 interacting protein 3.	SERPIN domain-containing protein; Belongs to the serpin family.	0.427
W5P9M9_SHEEP	CRNN	ENSOARP00000007138	ENSOARP00000022671	SERPIN domain-containing protein; Belongs to the serpin family.	Cornulin.	0.402
W5P9M9_SHEEP	CTSK	ENSOARP00000007138	ENSOARP00000022430	SERPIN domain-containing protein; Belongs to the serpin family.	Cathepsin K; Belongs to the peptidase C1 family.	0.576