STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM106BTransmembrane protein 106B. (275 aa)    
Predicted Functional Partners:
ARL4A
ADP-ribosylation factor-like 4A.
     
 0.818
CHMP2B
Charged multivesicular body protein 2B.
   
 
 0.815
C9orf72
C9orf72-SMCR8 complex subunit.
      
 0.799
SCIN
Scinderin.
     
 0.772
TMEM41B
Transmembrane protein 41B.
   
  
 0.747
PSAP
Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
      
 0.744
GRN
Granulin precursor.
      
 0.730
LAMP1
Lysosomal associated membrane protein 1.
    
 
 0.727
CTSD
Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
    
 
 0.713
PPT1
Palmitoyl-protein thioesterase 1.
      
 0.692
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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