EDEM1 protein (Ovis aries) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

EDEM1

alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (656 aa)

Predicted Functional Partners:

DNAJB9

0.865

SEL1L

0.859

XBP1

0.841

CANX

0.807

SYVN1

0.785

DERL2

0.770

OS9

0.764

ATF6

0.744

SEL1L2

0.725

DERL1

0.723

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF6	CANX	ENSOARP00000011178	ENSOARP00000003393	Activating transcription factor 6.	Calnexin.	0.702
ATF6	DNAJB9	ENSOARP00000011178	ENSOARP00000003734	Activating transcription factor 6.	DnaJ heat shock protein family (Hsp40) member B9.	0.490
ATF6	EDEM1	ENSOARP00000011178	ENSOARP00000008328	Activating transcription factor 6.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.744
ATF6	SEL1L	ENSOARP00000011178	ENSOARP00000003196	Activating transcription factor 6.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.702
ATF6	SYVN1	ENSOARP00000011178	ENSOARP00000013874	Activating transcription factor 6.	Synoviolin 1.	0.456
ATF6	XBP1	ENSOARP00000011178	ENSOARP00000003151	Activating transcription factor 6.	BZIP domain-containing protein.	0.955
CANX	ATF6	ENSOARP00000003393	ENSOARP00000011178	Calnexin.	Activating transcription factor 6.	0.702
CANX	DERL1	ENSOARP00000003393	ENSOARP00000011741	Calnexin.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.483
CANX	DERL2	ENSOARP00000003393	ENSOARP00000003322	Calnexin.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.591
CANX	EDEM1	ENSOARP00000003393	ENSOARP00000008328	Calnexin.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.807
CANX	OS9	ENSOARP00000003393	ENSOARP00000005994	Calnexin.	OS9 endoplasmic reticulum lectin.	0.671
CANX	SEL1L	ENSOARP00000003393	ENSOARP00000003196	Calnexin.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.611
CANX	SYVN1	ENSOARP00000003393	ENSOARP00000013874	Calnexin.	Synoviolin 1.	0.484
CANX	XBP1	ENSOARP00000003393	ENSOARP00000003151	Calnexin.	BZIP domain-containing protein.	0.675
DERL1	CANX	ENSOARP00000011741	ENSOARP00000003393	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Calnexin.	0.483
DERL1	DERL2	ENSOARP00000011741	ENSOARP00000003322	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.994
DERL1	DNAJB9	ENSOARP00000011741	ENSOARP00000003734	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	DnaJ heat shock protein family (Hsp40) member B9.	0.423
DERL1	EDEM1	ENSOARP00000011741	ENSOARP00000008328	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.723
DERL1	OS9	ENSOARP00000011741	ENSOARP00000005994	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.973
DERL1	SEL1L	ENSOARP00000011741	ENSOARP00000003196	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.981