node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCYAP1 | CRH | ENSOARP00000010237 | ENSOARP00000018668 | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | 0.648 |
ADCYAP1 | GHRH | ENSOARP00000010237 | ENSOARP00000019136 | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | 0.644 |
ADCYAP1 | W5PD67_SHEEP | ENSOARP00000010237 | ENSOARP00000008379 | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). | Uncharacterized protein. | 0.531 |
AP5B1 | LOC101118990 | ENSOARP00000019127 | ENSOARP00000014570 | Adaptor related protein complex 5 subunit beta 1. | Uncharacterized protein; Belongs to the GST superfamily. | 0.621 |
AP5B1 | W5PD67_SHEEP | ENSOARP00000019127 | ENSOARP00000008379 | Adaptor related protein complex 5 subunit beta 1. | Uncharacterized protein. | 0.534 |
AP5B1 | W5PVN0_SHEEP | ENSOARP00000019127 | ENSOARP00000014513 | Adaptor related protein complex 5 subunit beta 1. | Uncharacterized protein; Belongs to the GST superfamily. | 0.621 |
CRH | ADCYAP1 | ENSOARP00000018668 | ENSOARP00000010237 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). | 0.648 |
CRH | GHRH | ENSOARP00000018668 | ENSOARP00000019136 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | 0.725 |
CRH | UCN | ENSOARP00000018668 | ENSOARP00000020943 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Urocortin. | 0.995 |
CRH | W5PD67_SHEEP | ENSOARP00000018668 | ENSOARP00000008379 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Uncharacterized protein. | 0.482 |
GHRH | ADCYAP1 | ENSOARP00000019136 | ENSOARP00000010237 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). | 0.644 |
GHRH | CRH | ENSOARP00000019136 | ENSOARP00000018668 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | 0.725 |
GHRH | W5PD67_SHEEP | ENSOARP00000019136 | ENSOARP00000008379 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | Uncharacterized protein. | 0.445 |
LOC101118990 | AP5B1 | ENSOARP00000014570 | ENSOARP00000019127 | Uncharacterized protein; Belongs to the GST superfamily. | Adaptor related protein complex 5 subunit beta 1. | 0.621 |
LOC101118990 | W5PD67_SHEEP | ENSOARP00000014570 | ENSOARP00000008379 | Uncharacterized protein; Belongs to the GST superfamily. | Uncharacterized protein. | 0.481 |
LOC101118990 | W5PVN0_SHEEP | ENSOARP00000014570 | ENSOARP00000014513 | Uncharacterized protein; Belongs to the GST superfamily. | Uncharacterized protein; Belongs to the GST superfamily. | 0.655 |
PTHLH | W5PD67_SHEEP | ENSOARP00000021119 | ENSOARP00000008379 | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity o [...] | Uncharacterized protein. | 0.481 |
RBMX | W5PD67_SHEEP | ENSOARP00000011670 | ENSOARP00000008379 | RRM domain-containing protein. | Uncharacterized protein. | 0.446 |
UCN | CRH | ENSOARP00000020943 | ENSOARP00000018668 | Urocortin. | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | 0.995 |
UCN | W5PD67_SHEEP | ENSOARP00000020943 | ENSOARP00000008379 | Urocortin. | Uncharacterized protein. | 0.482 |