node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRH | CRHBP | ENSOARP00000018668 | ENSOARP00000018214 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy; Belongs to the CRF-binding protein family. | 0.994 |
CRH | CRHR2 | ENSOARP00000018668 | ENSOARP00000008466 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.999 |
CRH | GNB2 | ENSOARP00000018668 | ENSOARP00000017477 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | G protein subunit beta 2. | 0.491 |
CRH | GNB4 | ENSOARP00000018668 | ENSOARP00000022245 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | G protein subunit beta 4. | 0.491 |
CRH | NPVF | ENSOARP00000018668 | ENSOARP00000010970 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Pro-FMRFamide-related neuropeptide VF; Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity). May act in concert with kisspeptin, through opposing affects, to regulate the activity of gonadotropin-releasing hormone (GnRH) neurons across the seasons, leading to an annual change in fertility and the cyclical seasonal transition from non-breeding to breed [...] | 0.666 |
CRH | UCN | ENSOARP00000018668 | ENSOARP00000020943 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Urocortin. | 0.995 |
CRH | UCN2 | ENSOARP00000018668 | ENSOARP00000015214 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Urocortin 2. | 0.980 |
CRH | W5P3E3_SHEEP | ENSOARP00000018668 | ENSOARP00000004943 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | CRF domain-containing protein. | 0.602 |
CRHBP | CRH | ENSOARP00000018214 | ENSOARP00000018668 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy; Belongs to the CRF-binding protein family. | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | 0.994 |
CRHBP | CRHR2 | ENSOARP00000018214 | ENSOARP00000008466 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy; Belongs to the CRF-binding protein family. | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.916 |
CRHBP | UCN | ENSOARP00000018214 | ENSOARP00000020943 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy; Belongs to the CRF-binding protein family. | Urocortin. | 0.955 |
CRHBP | W5P3E3_SHEEP | ENSOARP00000018214 | ENSOARP00000004943 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy; Belongs to the CRF-binding protein family. | CRF domain-containing protein. | 0.482 |
CRHR2 | CRH | ENSOARP00000008466 | ENSOARP00000018668 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | 0.999 |
CRHR2 | CRHBP | ENSOARP00000008466 | ENSOARP00000018214 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy; Belongs to the CRF-binding protein family. | 0.916 |
CRHR2 | GNB2 | ENSOARP00000008466 | ENSOARP00000017477 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | G protein subunit beta 2. | 0.693 |
CRHR2 | GNB4 | ENSOARP00000008466 | ENSOARP00000022245 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | G protein subunit beta 4. | 0.693 |
CRHR2 | LAMP5 | ENSOARP00000008466 | ENSOARP00000010621 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | Lysosomal associated membrane protein family member 5. | 0.658 |
CRHR2 | NPVF | ENSOARP00000008466 | ENSOARP00000010970 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | Pro-FMRFamide-related neuropeptide VF; Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity). May act in concert with kisspeptin, through opposing affects, to regulate the activity of gonadotropin-releasing hormone (GnRH) neurons across the seasons, leading to an annual change in fertility and the cyclical seasonal transition from non-breeding to breed [...] | 0.750 |
CRHR2 | UCN | ENSOARP00000008466 | ENSOARP00000020943 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | Urocortin. | 0.998 |
CRHR2 | UCN2 | ENSOARP00000008466 | ENSOARP00000015214 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | Urocortin 2. | 0.991 |