NPC1 protein (Ovis aries) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Coexpression

Experiments

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[Homology]

Score

NPC1

NPC intracellular cholesterol transporter 1. (1275 aa)

Predicted Functional Partners:

NPC2

0.990

SREBF2

0.757

SREBF1

0.740

MYCN

0.695

GP2

0.683

LAMP1

0.670

OSBP

0.639

INSIG2

0.630

ABCA1

0.583

INSIG1

0.581

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	INSIG1	ENSOARP00000007886	ENSOARP00000007077	ATP binding cassette subfamily A member 1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.610
ABCA1	INSIG2	ENSOARP00000007886	ENSOARP00000013097	ATP binding cassette subfamily A member 1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.444
ABCA1	NPC1	ENSOARP00000007886	ENSOARP00000008490	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.583
ABCA1	NPC2	ENSOARP00000007886	ENSOARP00000001118	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 2.	0.465
ABCA1	SREBF1	ENSOARP00000007886	ENSOARP00000001571	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 1.	0.564
ABCA1	SREBF2	ENSOARP00000007886	ENSOARP00000020098	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 2.	0.604
GP2	NPC1	ENSOARP00000013367	ENSOARP00000008490	Glycoprotein 2.	NPC intracellular cholesterol transporter 1.	0.683
INSIG1	ABCA1	ENSOARP00000007077	ENSOARP00000007886	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	ATP binding cassette subfamily A member 1.	0.610
INSIG1	NPC1	ENSOARP00000007077	ENSOARP00000008490	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	NPC intracellular cholesterol transporter 1.	0.581
INSIG1	SREBF1	ENSOARP00000007077	ENSOARP00000001571	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 1.	0.750
INSIG1	SREBF2	ENSOARP00000007077	ENSOARP00000020098	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 2.	0.770
INSIG2	ABCA1	ENSOARP00000013097	ENSOARP00000007886	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	ATP binding cassette subfamily A member 1.	0.444
INSIG2	NPC1	ENSOARP00000013097	ENSOARP00000008490	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	NPC intracellular cholesterol transporter 1.	0.630
INSIG2	SREBF1	ENSOARP00000013097	ENSOARP00000001571	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 1.	0.631
INSIG2	SREBF2	ENSOARP00000013097	ENSOARP00000020098	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 2.	0.578
LAMP1	NPC1	ENSOARP00000008813	ENSOARP00000008490	Lysosomal associated membrane protein 1.	NPC intracellular cholesterol transporter 1.	0.670
LAMP1	NPC2	ENSOARP00000008813	ENSOARP00000001118	Lysosomal associated membrane protein 1.	NPC intracellular cholesterol transporter 2.	0.527
MYCN	NPC1	ENSOARP00000017676	ENSOARP00000008490	MYCN proto-oncogene, bHLH transcription factor.	NPC intracellular cholesterol transporter 1.	0.695
NPC1	ABCA1	ENSOARP00000008490	ENSOARP00000007886	NPC intracellular cholesterol transporter 1.	ATP binding cassette subfamily A member 1.	0.583
NPC1	GP2	ENSOARP00000008490	ENSOARP00000013367	NPC intracellular cholesterol transporter 1.	Glycoprotein 2.	0.683