| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CXCL8 | NFKB1 | ENSOARP00000015557 | ENSOARP00000013630 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. | Nuclear factor kappa B subunit 1. | 0.927 |
| CXCL8 | RELA | ENSOARP00000015557 | ENSOARP00000018707 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. | RELA proto-oncogene, NF-kB subunit. | 0.901 |
| CXCL8 | TNF | ENSOARP00000015557 | ENSOARP00000008936 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.935 |
| CXCL8-2 | TNF | ENSOARP00000018194 | ENSOARP00000008936 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.920 |
| LTA | TNF | ENSOARP00000009101 | ENSOARP00000008936 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.907 |
| LTA | TNFRSF1A | ENSOARP00000009101 | ENSOARP00000022803 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | Uncharacterized protein. | 0.998 |
| LTA | TNFRSF1B | ENSOARP00000009101 | ENSOARP00000018463 | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. | TNF receptor superfamily member 1B. | 0.971 |
| NFKB1 | CXCL8 | ENSOARP00000013630 | ENSOARP00000015557 | Nuclear factor kappa B subunit 1. | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. | 0.927 |
| NFKB1 | RELA | ENSOARP00000013630 | ENSOARP00000018707 | Nuclear factor kappa B subunit 1. | RELA proto-oncogene, NF-kB subunit. | 0.999 |
| NFKB1 | TNF | ENSOARP00000013630 | ENSOARP00000008936 | Nuclear factor kappa B subunit 1. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.908 |
| PSME1 | PSME2 | ENSOARP00000020647 | ENSOARP00000020639 | Proteasome activator subunit 1. | Proteasome activator subunit 2. | 0.999 |
| PSME1 | PSME3 | ENSOARP00000020647 | ENSOARP00000003986 | Proteasome activator subunit 1. | Proteasome activator subunit 3. | 0.934 |
| PSME1 | TNF | ENSOARP00000020647 | ENSOARP00000008936 | Proteasome activator subunit 1. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.905 |
| PSME2 | PSME1 | ENSOARP00000020639 | ENSOARP00000020647 | Proteasome activator subunit 2. | Proteasome activator subunit 1. | 0.999 |
| PSME2 | PSME3 | ENSOARP00000020639 | ENSOARP00000003986 | Proteasome activator subunit 2. | Proteasome activator subunit 3. | 0.913 |
| PSME2 | TNF | ENSOARP00000020639 | ENSOARP00000008936 | Proteasome activator subunit 2. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.911 |
| PSME3 | PSME1 | ENSOARP00000003986 | ENSOARP00000020647 | Proteasome activator subunit 3. | Proteasome activator subunit 1. | 0.934 |
| PSME3 | PSME2 | ENSOARP00000003986 | ENSOARP00000020639 | Proteasome activator subunit 3. | Proteasome activator subunit 2. | 0.913 |
| PSME3 | TNF | ENSOARP00000003986 | ENSOARP00000008936 | Proteasome activator subunit 3. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.905 |
| RELA | CXCL8 | ENSOARP00000018707 | ENSOARP00000015557 | RELA proto-oncogene, NF-kB subunit. | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. | 0.901 |