node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IKBKB | IKBKG | ENSOARP00000003470 | ENSOARP00000004340 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.999 |
IKBKB | IL10 | ENSOARP00000003470 | ENSOARP00000006744 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | Interleukin-10 precursor; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cy [...] | 0.521 |
IKBKB | NFKB1 | ENSOARP00000003470 | ENSOARP00000013630 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | Nuclear factor nf-kappa-b p105 subunit isoform x1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.997 |
IKBKB | RELA | ENSOARP00000003470 | ENSOARP00000018707 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | RELA proto-oncogene, NF-kB subunit; V-rel avian reticuloendotheliosis viral oncogene homolog A | 0.998 |
IKBKB | RIPK1 | ENSOARP00000003470 | ENSOARP00000001620 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | Receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.922 |
IKBKB | TNF | ENSOARP00000003470 | ENSOARP00000008936 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | Tumor necrosis factor superfamily, member 2; Tumor necrosis factor; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation | 0.979 |
IKBKB | TNFAIP3 | ENSOARP00000003470 | ENSOARP00000000580 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | Tumor necrosis factor alpha-induced protein 3 isoform x1; Tumor necrosis factor, alpha-induced protein 3 | 0.950 |
IKBKB | TNFRSF1A | ENSOARP00000003470 | ENSOARP00000022803 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | Uncharacterized protein; Ovis aries tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mRNA | 0.998 |
IKBKB | TRADD | ENSOARP00000003470 | ENSOARP00000002885 | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | TNFRSF1A-associated via death domain | 0.914 |
IKBKG | IKBKB | ENSOARP00000004340 | ENSOARP00000003470 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | 0.999 |
IKBKG | NFKB1 | ENSOARP00000004340 | ENSOARP00000013630 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Nuclear factor nf-kappa-b p105 subunit isoform x1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.986 |
IKBKG | RELA | ENSOARP00000004340 | ENSOARP00000018707 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | RELA proto-oncogene, NF-kB subunit; V-rel avian reticuloendotheliosis viral oncogene homolog A | 0.989 |
IKBKG | RIPK1 | ENSOARP00000004340 | ENSOARP00000001620 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.994 |
IKBKG | TNF | ENSOARP00000004340 | ENSOARP00000008936 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Tumor necrosis factor superfamily, member 2; Tumor necrosis factor; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation | 0.995 |
IKBKG | TNFAIP3 | ENSOARP00000004340 | ENSOARP00000000580 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Tumor necrosis factor alpha-induced protein 3 isoform x1; Tumor necrosis factor, alpha-induced protein 3 | 0.986 |
IKBKG | TNFRSF1A | ENSOARP00000004340 | ENSOARP00000022803 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Uncharacterized protein; Ovis aries tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mRNA | 0.990 |
IKBKG | TRADD | ENSOARP00000004340 | ENSOARP00000002885 | Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | TNFRSF1A-associated via death domain | 0.938 |
IL10 | IKBKB | ENSOARP00000006744 | ENSOARP00000003470 | Interleukin-10 precursor; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cy [...] | Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta | 0.521 |
IL10 | NFKB1 | ENSOARP00000006744 | ENSOARP00000013630 | Interleukin-10 precursor; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cy [...] | Nuclear factor nf-kappa-b p105 subunit isoform x1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.456 |
IL10 | RELA | ENSOARP00000006744 | ENSOARP00000018707 | Interleukin-10 precursor; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cy [...] | RELA proto-oncogene, NF-kB subunit; V-rel avian reticuloendotheliosis viral oncogene homolog A | 0.471 |