STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFTumor necrosis factor superfamily, member 2; Tumor necrosis factor; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (234 aa)    
Predicted Functional Partners:
TNFRSF1B
Tumor necrosis factor receptor superfamily, member 1B
   
 0.999
TNFRSF1A
Uncharacterized protein; Ovis aries tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mRNA
   
 0.999
TRADD
TNFRSF1A-associated via death domain
   
 0.996
RIPK1
Receptor (TNFRSF)-interacting serine-threonine kinase 1
   
 0.995
IKBKG
Inhibitor of nuclear factor kappa-b kinase subunit gamma; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    
 0.995
RELA
RELA proto-oncogene, NF-kB subunit; V-rel avian reticuloendotheliosis viral oncogene homolog A
    
 0.992
TNFAIP3
Tumor necrosis factor alpha-induced protein 3 isoform x1; Tumor necrosis factor, alpha-induced protein 3
   
 0.990
NFKB1
Nuclear factor nf-kappa-b p105 subunit isoform x1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
   
 0.986
IKBKB
Inhibitor of nuclear factor kappa-b kinase subunit beta isoform x1; Inhibitor of nuclear factor kappa B kinase subunit beta
   
 0.979
IL10
Interleukin-10 precursor; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cy [...]
   
 
 0.977
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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