LOC101103376 protein (Ovis aries) - STRING interaction network

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Score

LOC101103376

Uncharacterized protein. (186 aa)

Predicted Functional Partners:

IFNAR1

0.854

JAK1

0.612

IFNAR2

0.608

IRF9

0.595

IL10RB

0.574

TBK1

0.568

DDX58

0.567

ISG15

0.563

TYK2

0.548

IRF3

0.544

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX58	IFNAR1	ENSOARP00000015803	ENSOARP00000014132	DExD/H-box helicase 58.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.419
DDX58	IRF3	ENSOARP00000015803	ENSOARP00000014293	DExD/H-box helicase 58.	Interferon regulatory factor 3.	0.806
DDX58	IRF9	ENSOARP00000015803	ENSOARP00000020626	DExD/H-box helicase 58.	Interferon regulatory factor 9.	0.620
DDX58	ISG15	ENSOARP00000015803	ENSOARP00000007752	DExD/H-box helicase 58.	Uncharacterized protein.	0.996
DDX58	JAK1	ENSOARP00000015803	ENSOARP00000010851	DExD/H-box helicase 58.	Tyrosine-protein kinase.	0.514
DDX58	LOC101103376	ENSOARP00000015803	ENSOARP00000009307	DExD/H-box helicase 58.	Uncharacterized protein.	0.567
DDX58	TBK1	ENSOARP00000015803	ENSOARP00000003587	DExD/H-box helicase 58.	TANK binding kinase 1.	0.754
DDX58	TYK2	ENSOARP00000015803	ENSOARP00000017200	DExD/H-box helicase 58.	Tyrosine-protein kinase.	0.414
IFNAR1	DDX58	ENSOARP00000014132	ENSOARP00000015803	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	DExD/H-box helicase 58.	0.419
IFNAR1	IFNAR2	ENSOARP00000014132	ENSOARP00000014268	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation. Mediates signal transduction via its association with the TYR kinase, JAK1.	0.999
IFNAR1	IL10RB	ENSOARP00000014132	ENSOARP00000014196	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interleukin 10 receptor subunit beta.	0.598
IFNAR1	IRF3	ENSOARP00000014132	ENSOARP00000014293	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interferon regulatory factor 3.	0.903
IFNAR1	IRF9	ENSOARP00000014132	ENSOARP00000020626	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interferon regulatory factor 9.	0.874
IFNAR1	ISG15	ENSOARP00000014132	ENSOARP00000007752	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Uncharacterized protein.	0.771
IFNAR1	JAK1	ENSOARP00000014132	ENSOARP00000010851	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Tyrosine-protein kinase.	0.999
IFNAR1	LOC101103376	ENSOARP00000014132	ENSOARP00000009307	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Uncharacterized protein.	0.854
IFNAR1	TBK1	ENSOARP00000014132	ENSOARP00000003587	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	TANK binding kinase 1.	0.750
IFNAR1	TYK2	ENSOARP00000014132	ENSOARP00000017200	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Tyrosine-protein kinase.	0.999
IFNAR2	IFNAR1	ENSOARP00000014268	ENSOARP00000014132	Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation. Mediates signal transduction via its association with the TYR kinase, JAK1.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.999
IFNAR2	IL10RB	ENSOARP00000014268	ENSOARP00000014196	Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation. Mediates signal transduction via its association with the TYR kinase, JAK1.	Interleukin 10 receptor subunit beta.	0.782