STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPOAP1TSPO associated protein 1. (1803 aa)    
Predicted Functional Partners:
RIMS2
Regulating synaptic membrane exocytosis 2.
    
 0.978
TSPO
Translocator protein; Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.
    
 0.907
W5PNB9_SHEEP
C2 domain-containing protein.
    
 0.802
UNC13B
Unc-13 homolog B.
   
 0.765
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
     
 0.635
RIMS3
Regulating synaptic membrane exocytosis 3.
    
 0.625
ACBD3
Acyl-CoA binding domain containing 3.
      
 0.622
MAPK8IP2
Mitogen-activated protein kinase 8 interacting protein 2.
   
 
 0.579
RIMS4
Regulating synaptic membrane exocytosis 4.
    
 0.577
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
   
 
 0.575
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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