| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BGLAP | BMP2 | ENSOARP00000006028 | ENSOARP00000020124 | Osteocalcin; Binds strongly to apatite and calcium. | Bone morphogenetic protein 2. | 0.825 |
| BGLAP | CBFB | ENSOARP00000006028 | ENSOARP00000002838 | Osteocalcin; Binds strongly to apatite and calcium. | Core-binding factor subunit beta. | 0.459 |
| BGLAP | COL10A1 | ENSOARP00000006028 | ENSOARP00000010101 | Osteocalcin; Binds strongly to apatite and calcium. | Collagen type X alpha 1 chain. | 0.507 |
| BGLAP | PRKACA | ENSOARP00000006028 | ENSOARP00000006933 | Osteocalcin; Binds strongly to apatite and calcium. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.400 |
| BGLAP | RUNX2 | ENSOARP00000006028 | ENSOARP00000011107 | Osteocalcin; Binds strongly to apatite and calcium. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.948 |
| BGLAP | SOX9 | ENSOARP00000006028 | ENSOARP00000014771 | Osteocalcin; Binds strongly to apatite and calcium. | SRY-box transcription factor 9. | 0.662 |
| BGLAP | SPP1 | ENSOARP00000006028 | ENSOARP00000002753 | Osteocalcin; Binds strongly to apatite and calcium. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.931 |
| BMP2 | BGLAP | ENSOARP00000020124 | ENSOARP00000006028 | Bone morphogenetic protein 2. | Osteocalcin; Binds strongly to apatite and calcium. | 0.825 |
| BMP2 | COL10A1 | ENSOARP00000020124 | ENSOARP00000010101 | Bone morphogenetic protein 2. | Collagen type X alpha 1 chain. | 0.518 |
| BMP2 | RUNX2 | ENSOARP00000020124 | ENSOARP00000011107 | Bone morphogenetic protein 2. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.892 |
| BMP2 | SOX9 | ENSOARP00000020124 | ENSOARP00000014771 | Bone morphogenetic protein 2. | SRY-box transcription factor 9. | 0.649 |
| BMP2 | SPP1 | ENSOARP00000020124 | ENSOARP00000002753 | Bone morphogenetic protein 2. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.828 |
| CBFB | BGLAP | ENSOARP00000002838 | ENSOARP00000006028 | Core-binding factor subunit beta. | Osteocalcin; Binds strongly to apatite and calcium. | 0.459 |
| CBFB | RUNX2 | ENSOARP00000002838 | ENSOARP00000011107 | Core-binding factor subunit beta. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.956 |
| CBFB | SPP1 | ENSOARP00000002838 | ENSOARP00000002753 | Core-binding factor subunit beta. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.413 |
| COL10A1 | BGLAP | ENSOARP00000010101 | ENSOARP00000006028 | Collagen type X alpha 1 chain. | Osteocalcin; Binds strongly to apatite and calcium. | 0.507 |
| COL10A1 | BMP2 | ENSOARP00000010101 | ENSOARP00000020124 | Collagen type X alpha 1 chain. | Bone morphogenetic protein 2. | 0.518 |
| COL10A1 | RUNX2 | ENSOARP00000010101 | ENSOARP00000011107 | Collagen type X alpha 1 chain. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.909 |
| COL10A1 | SOX9 | ENSOARP00000010101 | ENSOARP00000014771 | Collagen type X alpha 1 chain. | SRY-box transcription factor 9. | 0.812 |
| COL10A1 | SPP1 | ENSOARP00000010101 | ENSOARP00000002753 | Collagen type X alpha 1 chain. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.504 |
