STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (532 aa)    
Predicted Functional Partners:
BOP1
BOP1 ribosomal biogenesis factor.
      
 0.825
LOC101103343
Uncharacterized protein.
    
 0.752
TMIE
Transmembrane inner ear.
      
 0.702
LOC101120999
C-type lectin domain-containing protein.
    
 0.643
TMC1
Transmembrane channel-like protein.
    
 0.624
CEACAM16
Carcinoembryonic antigen related cell adhesion molecule 16.
    
 0.607
GIPC3
GIPC PDZ domain containing family member 3.
   
 
 0.593
CD109
CD109 molecule.
    
 0.573
SERPINA5
Serpin family A member 5; Belongs to the serpin family.
    
 0.559
GJB2
Gap junction beta-2 protein; Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).
   
  
 0.540
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.