STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JCHAINJoining chain of multimeric IgA and IgM. (159 aa)    
Predicted Functional Partners:
PIGR
Polymeric immunoglobulin receptor.
  
 0.998
W5PGE9_SHEEP
Uncharacterized protein.
   
 0.917
PIGA
Phosphatidylinositol glycan anchor biosynthesis class A.
      
 0.893
MZB1
Marginal zone B and B1 cell specific protein.
   
  
 0.872
FCMR
Fc fragment of IgM receptor.
   
 0.819
IGHM
Immunoglobulin heavy constant mu.
   
 0.812
IL2
Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.
    
 
 0.758
MIGA2
Mitoguardin 2.
      
 0.753
POU2AF1
POU class 2 homeobox associating factor 1.
   
  
 0.739
CD79A
CD79a molecule.
   
 
 0.719
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.