PGFS protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PGFS

Aldo_ket_red domain-containing protein. (353 aa)

Predicted Functional Partners:

HPGDS

0.949

CYP19

0.918

LOC101120331

0.917

AKR1B1

0.909

CYP1B1

0.907

HSD3B1

0.906

CYP17A1

0.905

CYP7A1

0.905

AKR1D1

0.902

CYP2E1

0.901

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1B1	PGFS	ENSOARP00000007961	ENSOARP00000012719	Aldo_ket_red domain-containing protein.	Aldo_ket_red domain-containing protein.	0.909
AKR1D1	CYP17A1	ENSOARP00000010776	ENSOARP00000002254	Aldo-keto reductase family 1 member D1.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.924
AKR1D1	CYP19	ENSOARP00000010776	ENSOARP00000022542	Aldo-keto reductase family 1 member D1.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.917
AKR1D1	CYP7A1	ENSOARP00000010776	ENSOARP00000016589	Aldo-keto reductase family 1 member D1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.400
AKR1D1	HSD3B1	ENSOARP00000010776	ENSOARP00000021913	Aldo-keto reductase family 1 member D1.	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.906
AKR1D1	PGFS	ENSOARP00000010776	ENSOARP00000012719	Aldo-keto reductase family 1 member D1.	Aldo_ket_red domain-containing protein.	0.902
CYP17A1	AKR1D1	ENSOARP00000002254	ENSOARP00000010776	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Aldo-keto reductase family 1 member D1.	0.924
CYP17A1	CYP19	ENSOARP00000002254	ENSOARP00000022542	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.956
CYP17A1	CYP2E1	ENSOARP00000002254	ENSOARP00000000021	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.920
CYP17A1	CYP7A1	ENSOARP00000002254	ENSOARP00000016589	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.935
CYP17A1	HSD3B1	ENSOARP00000002254	ENSOARP00000021913	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.985
CYP17A1	PGFS	ENSOARP00000002254	ENSOARP00000012719	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Aldo_ket_red domain-containing protein.	0.905
CYP19	AKR1D1	ENSOARP00000022542	ENSOARP00000010776	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Aldo-keto reductase family 1 member D1.	0.917
CYP19	CYP17A1	ENSOARP00000022542	ENSOARP00000002254	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.956
CYP19	CYP1B1	ENSOARP00000022542	ENSOARP00000009752	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.771
CYP19	CYP7A1	ENSOARP00000022542	ENSOARP00000016589	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.642
CYP19	HSD3B1	ENSOARP00000022542	ENSOARP00000021913	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.979
CYP19	LOC101120331	ENSOARP00000022542	ENSOARP00000010752	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Sulfotransferase; Belongs to the sulfotransferase 1 family.	0.949
CYP19	PGFS	ENSOARP00000022542	ENSOARP00000012719	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Aldo_ket_red domain-containing protein.	0.918
CYP1B1	CYP19	ENSOARP00000009752	ENSOARP00000022542	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.771