NANP protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NANP

N-acetylneuraminic acid phosphatase. (248 aa)

Predicted Functional Partners:

NANS

0.960

RSPH3

0.939

LOC101106806

0.918

GNE

0.782

NT5E

0.761

PSAT1

0.757

KCNE5

0.739

W5NRS0_SHEEP

0.656

MTAP

0.646

KLHL3

0.601

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNE	NANP	ENSOARP00000012431	ENSOARP00000013185	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	N-acetylneuraminic acid phosphatase.	0.782
GNE	NANS	ENSOARP00000012431	ENSOARP00000011948	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	N-acetylneuraminate synthase.	0.958
KCNE5	NANP	ENSOARP00000019297	ENSOARP00000013185	Potassium voltage-gated channel subfamily E regulatory subunit 5.	N-acetylneuraminic acid phosphatase.	0.739
KLHL3	NANP	ENSOARP00000016491	ENSOARP00000013185	Kelch like family member 3.	N-acetylneuraminic acid phosphatase.	0.601
KLHL3	RSPH3	ENSOARP00000016491	ENSOARP00000004766	Kelch like family member 3.	Radial spoke head 3.	0.541
LOC101106806	NANP	ENSOARP00000005204	ENSOARP00000013185	Rieske domain-containing protein.	N-acetylneuraminic acid phosphatase.	0.918
LOC101106806	NANS	ENSOARP00000005204	ENSOARP00000011948	Rieske domain-containing protein.	N-acetylneuraminate synthase.	0.930
MTAP	NANP	ENSOARP00000015465	ENSOARP00000013185	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	N-acetylneuraminic acid phosphatase.	0.646
MTAP	NT5E	ENSOARP00000015465	ENSOARP00000014235	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.873
MTAP	PSAT1	ENSOARP00000015465	ENSOARP00000013240	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	Phosphoserine aminotransferase.	0.415
MTAP	W5NRS0_SHEEP	ENSOARP00000015465	ENSOARP00000000860	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	PNP_UDP_1 domain-containing protein.	0.442
NANP	GNE	ENSOARP00000013185	ENSOARP00000012431	N-acetylneuraminic acid phosphatase.	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	0.782
NANP	KCNE5	ENSOARP00000013185	ENSOARP00000019297	N-acetylneuraminic acid phosphatase.	Potassium voltage-gated channel subfamily E regulatory subunit 5.	0.739
NANP	KLHL3	ENSOARP00000013185	ENSOARP00000016491	N-acetylneuraminic acid phosphatase.	Kelch like family member 3.	0.601
NANP	LOC101106806	ENSOARP00000013185	ENSOARP00000005204	N-acetylneuraminic acid phosphatase.	Rieske domain-containing protein.	0.918
NANP	MTAP	ENSOARP00000013185	ENSOARP00000015465	N-acetylneuraminic acid phosphatase.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.646
NANP	NANS	ENSOARP00000013185	ENSOARP00000011948	N-acetylneuraminic acid phosphatase.	N-acetylneuraminate synthase.	0.960
NANP	NT5E	ENSOARP00000013185	ENSOARP00000014235	N-acetylneuraminic acid phosphatase.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.761
NANP	PSAT1	ENSOARP00000013185	ENSOARP00000013240	N-acetylneuraminic acid phosphatase.	Phosphoserine aminotransferase.	0.757
NANP	RSPH3	ENSOARP00000013185	ENSOARP00000004766	N-acetylneuraminic acid phosphatase.	Radial spoke head 3.	0.939