TCF3 protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	EP300	ENSOARP00000017049	ENSOARP00000019268	Achaete-scute family bHLH transcription factor 1.	E1A binding protein p300.	0.525
ASCL1	TCF3	ENSOARP00000017049	ENSOARP00000013391	Achaete-scute family bHLH transcription factor 1.	Transcription factor 3.	0.869
CREBBP	CTNNB1	ENSOARP00000002661	ENSOARP00000003072	CREB binding protein.	Catenin beta 1.	0.998
CREBBP	EP300	ENSOARP00000002661	ENSOARP00000019268	CREB binding protein.	E1A binding protein p300.	0.999
CREBBP	MYOD1	ENSOARP00000002661	ENSOARP00000022800	CREB binding protein.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.879
CREBBP	MYOG	ENSOARP00000002661	ENSOARP00000001076	CREB binding protein.	BASIC domain-containing protein.	0.406
CREBBP	TAL1	ENSOARP00000002661	ENSOARP00000003681	CREB binding protein.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.582
CREBBP	TCF3	ENSOARP00000002661	ENSOARP00000013391	CREB binding protein.	Transcription factor 3.	0.945
CTNNB1	CREBBP	ENSOARP00000003072	ENSOARP00000002661	Catenin beta 1.	CREB binding protein.	0.998
CTNNB1	EP300	ENSOARP00000003072	ENSOARP00000019268	Catenin beta 1.	E1A binding protein p300.	0.997
CTNNB1	MYOD1	ENSOARP00000003072	ENSOARP00000022800	Catenin beta 1.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.442
CTNNB1	TCF3	ENSOARP00000003072	ENSOARP00000013391	Catenin beta 1.	Transcription factor 3.	0.973
EP300	ASCL1	ENSOARP00000019268	ENSOARP00000017049	E1A binding protein p300.	Achaete-scute family bHLH transcription factor 1.	0.525
EP300	CREBBP	ENSOARP00000019268	ENSOARP00000002661	E1A binding protein p300.	CREB binding protein.	0.999
EP300	CTNNB1	ENSOARP00000019268	ENSOARP00000003072	E1A binding protein p300.	Catenin beta 1.	0.997
EP300	ID1	ENSOARP00000019268	ENSOARP00000001150	E1A binding protein p300.	Inhibitor of DNA binding 1, HLH protein.	0.443
EP300	MYOD1	ENSOARP00000019268	ENSOARP00000022800	E1A binding protein p300.	Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.948
EP300	MYOG	ENSOARP00000019268	ENSOARP00000001076	E1A binding protein p300.	BASIC domain-containing protein.	0.517
EP300	TAL1	ENSOARP00000019268	ENSOARP00000003681	E1A binding protein p300.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.821
EP300	TCF3	ENSOARP00000019268	ENSOARP00000013391	E1A binding protein p300.	Transcription factor 3.	0.872