IPO7 protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Export your current network:

... as a bitmap image:

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file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

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same PNG format, but at higher resolution

... as a vector graphic:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRD1	IPO4	ENSOARP00000016020	ENSOARP00000020612	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Importin 4.	0.549
ADGRD1	IPO5	ENSOARP00000016020	ENSOARP00000003018	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Importin 5.	0.802
ADGRD1	IPO7	ENSOARP00000016020	ENSOARP00000013594	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Importin 7.	0.773
ADGRD1	IPO9	ENSOARP00000016020	ENSOARP00000020499	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Importin 9.	0.662
ADGRD1	KPNB1	ENSOARP00000016020	ENSOARP00000009086	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Karyopherin subunit beta 1.	0.913
ADGRD1	NUP153	ENSOARP00000016020	ENSOARP00000012343	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Nucleoporin 153.	0.771
ADGRD1	TNPO1	ENSOARP00000016020	ENSOARP00000005404	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Transportin 1.	0.641
AGO2	IPO7	ENSOARP00000004023	ENSOARP00000013594	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Importin 7.	0.801
AGO2	RAN	ENSOARP00000004023	ENSOARP00000016488	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.586
IPO4	ADGRD1	ENSOARP00000020612	ENSOARP00000016020	Importin 4.	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	0.549
IPO4	IPO5	ENSOARP00000020612	ENSOARP00000003018	Importin 4.	Importin 5.	0.933
IPO4	IPO7	ENSOARP00000020612	ENSOARP00000013594	Importin 4.	Importin 7.	0.865
IPO4	IPO9	ENSOARP00000020612	ENSOARP00000020499	Importin 4.	Importin 9.	0.918
IPO4	KPNB1	ENSOARP00000020612	ENSOARP00000009086	Importin 4.	Karyopherin subunit beta 1.	0.922
IPO4	NUP153	ENSOARP00000020612	ENSOARP00000012343	Importin 4.	Nucleoporin 153.	0.612
IPO4	RAN	ENSOARP00000020612	ENSOARP00000016488	Importin 4.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.549
IPO4	TNPO1	ENSOARP00000020612	ENSOARP00000005404	Importin 4.	Transportin 1.	0.877
IPO5	ADGRD1	ENSOARP00000003018	ENSOARP00000016020	Importin 5.	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	0.802
IPO5	IPO4	ENSOARP00000003018	ENSOARP00000020612	Importin 5.	Importin 4.	0.933
IPO5	IPO7	ENSOARP00000003018	ENSOARP00000013594	Importin 5.	Importin 7.	0.933