| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDH1 | CDH3 | ENSOARP00000003691 | ENSOARP00000003674 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. | 0.631 |
| CDH1 | W5PU67_SHEEP | ENSOARP00000003691 | ENSOARP00000013998 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. | Uncharacterized protein. | 0.532 |
| CDH3 | CDH1 | ENSOARP00000003674 | ENSOARP00000003691 | Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. | 0.631 |
| CDH3 | W5PU67_SHEEP | ENSOARP00000003674 | ENSOARP00000013998 | Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. | Uncharacterized protein. | 0.470 |
| CTBP2 | KDM1A | ENSOARP00000011708 | ENSOARP00000008285 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.804 |
| CTBP2 | W5PU67_SHEEP | ENSOARP00000011708 | ENSOARP00000013998 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Uncharacterized protein. | 0.445 |
| CTBP2 | W5Q3P0_SHEEP | ENSOARP00000011708 | ENSOARP00000017329 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.837 |
| DNMT1 | KDM1A | ENSOARP00000016508 | ENSOARP00000008285 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.914 |
| DNMT1 | TP53 | ENSOARP00000016508 | ENSOARP00000016707 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.859 |
| DNMT1 | W5PU67_SHEEP | ENSOARP00000016508 | ENSOARP00000013998 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Uncharacterized protein. | 0.428 |
| HMG20B | KDM1A | ENSOARP00000013200 | ENSOARP00000008285 | High mobility group 20B. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.995 |
| HMG20B | W5PU67_SHEEP | ENSOARP00000013200 | ENSOARP00000013998 | High mobility group 20B. | Uncharacterized protein. | 0.461 |
| KDM1A | CTBP2 | ENSOARP00000008285 | ENSOARP00000011708 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.804 |
| KDM1A | DNMT1 | ENSOARP00000008285 | ENSOARP00000016508 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.914 |
| KDM1A | HMG20B | ENSOARP00000008285 | ENSOARP00000013200 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | High mobility group 20B. | 0.995 |
| KDM1A | TP53 | ENSOARP00000008285 | ENSOARP00000016707 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.909 |
| KDM1A | W5PU67_SHEEP | ENSOARP00000008285 | ENSOARP00000013998 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Uncharacterized protein. | 0.536 |
| KDM1A | W5Q3P0_SHEEP | ENSOARP00000008285 | ENSOARP00000017329 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.812 |
| MST1R | W5PU67_SHEEP | ENSOARP00000012165 | ENSOARP00000013998 | Macrophage stimulating 1 receptor. | Uncharacterized protein. | 0.493 |
| TP53 | DNMT1 | ENSOARP00000016707 | ENSOARP00000016508 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.859 |
