IL18R1 protein (Ovis aries) - STRING interaction network

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Score

IL18R1

Interleukin 18 receptor 1. (538 aa)

Predicted Functional Partners:

IL18

0.995

IL18RAP

0.993

IL37

0.949

W5QI58_SHEEP

0.709

IL12RB2

0.603

IL2RA

0.578

IL18BP

0.562

ORMDL3

0.533

IL33

0.531

MFSD9

0.524

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL12RB2	IL18R1	ENSOARP00000011984	ENSOARP00000014025	Uncharacterized protein.	Interleukin 18 receptor 1.	0.603
IL12RB2	IL2RA	ENSOARP00000011984	ENSOARP00000013772	Uncharacterized protein.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.434
IL18	IL18BP	ENSOARP00000017389	ENSOARP00000003719	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 binding protein.	0.932
IL18	IL18R1	ENSOARP00000017389	ENSOARP00000014025	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor 1.	0.995
IL18	IL18RAP	ENSOARP00000017389	ENSOARP00000014010	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor accessory protein.	0.989
IL18	IL2RA	ENSOARP00000017389	ENSOARP00000013772	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.556
IL18	IL33	ENSOARP00000017389	ENSOARP00000014614	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 33.	0.811
IL18	IL37	ENSOARP00000017389	ENSOARP00000022419	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-1.	0.709
IL18BP	IL18	ENSOARP00000003719	ENSOARP00000017389	Interleukin 18 binding protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.932
IL18BP	IL18R1	ENSOARP00000003719	ENSOARP00000014025	Interleukin 18 binding protein.	Interleukin 18 receptor 1.	0.562
IL18BP	IL18RAP	ENSOARP00000003719	ENSOARP00000014010	Interleukin 18 binding protein.	Interleukin 18 receptor accessory protein.	0.475
IL18BP	IL37	ENSOARP00000003719	ENSOARP00000022419	Interleukin 18 binding protein.	Interleukin-1.	0.945
IL18BP	W5QI58_SHEEP	ENSOARP00000003719	ENSOARP00000022409	Interleukin 18 binding protein.	Uncharacterized protein.	0.645
IL18R1	IL12RB2	ENSOARP00000014025	ENSOARP00000011984	Interleukin 18 receptor 1.	Uncharacterized protein.	0.603
IL18R1	IL18	ENSOARP00000014025	ENSOARP00000017389	Interleukin 18 receptor 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.995
IL18R1	IL18BP	ENSOARP00000014025	ENSOARP00000003719	Interleukin 18 receptor 1.	Interleukin 18 binding protein.	0.562
IL18R1	IL18RAP	ENSOARP00000014025	ENSOARP00000014010	Interleukin 18 receptor 1.	Interleukin 18 receptor accessory protein.	0.993
IL18R1	IL2RA	ENSOARP00000014025	ENSOARP00000013772	Interleukin 18 receptor 1.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.578
IL18R1	IL33	ENSOARP00000014025	ENSOARP00000014614	Interleukin 18 receptor 1.	Interleukin 33.	0.531
IL18R1	IL37	ENSOARP00000014025	ENSOARP00000022419	Interleukin 18 receptor 1.	Interleukin-1.	0.949